1) Inuyasha & Higurashi Kagome
-This is just my absolute favorite couple of all time. They look great together, and they are the perfect couple.
2) Himura Yuu & Amamiya Yuuko
-There's nothing else to say here.
3) Hotori Tadase & Hinamori Amu
-Such a cute couple...I love them. They are what made the series so enjoyable for me.
4) Kakizaki Megu & Suigintou
-Separately, they're both characters I dislike. Together, they contribute to what I think is one of the anime masterpieces of all time.
5) Hyuuga Natsume & Sakura Mikan
-If there is ever a sequel for Gakuen Alice, these two would probably become #3 on my list easily.
-Misaka Mikoto & Shirai Kuroko
-Sakurada Jun & Shinku
-Misaka Shiori & Misaka Kaori
-Kyon & Suzumiya Haruhi
-Aizawa Sho & Shiina Tsubasa
-Raballo & Claes
-Himura Kenshin & Tsukishiro Tomoe
-Touno Takaki & Shinohara Akari
-Francis Harcourt & Nadja Applefield
-Aizawa Yuuichi & Sawatari Makoto
-Amasawa Seiji & Tsukishima Shizuku
-Yagami Hayate & Vita
-Fukuji Mihoko & Ikeda Kana
-Li Syaoran & Kinomoto Sakura
-Marco Toni & Angelica
-Natsu Dragneel & Lisanna
-Ibuki Fuuko & Okazaki Ushio
-Shiina Hikaru & Shiina Tsubasa
-Nello & Alois
-Pazu & Sheeta
-Fujisawa Hiroki & Sawatari Sayuri
And here are some that I really like but not as much as others. Maybe Tier 3?
-Ikari Shinji & Soryu Asuka Langley
-Okazaki Tomoya & Furukawa Nagisa
-Chiaki Shinichi & Noda Megumi
-Ryuuya & Kanna
-Hiiragi Kagami & Izumi Konata
-Erio Mondial & Caro Ru Lushe
-Itou Chika & Matsuoka Miu
-Irie Naoki & Aihara Kotoko
-Jean & Henrietta
-Hirono Hiro & Shindou Kei
-Nakagami Shinichiro & Isurugi Noe
-Tombo Kopoli & Kiki